FB2026_02 , released June 18, 2026
Allele: Dmel\AdhF-ChD
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General Information
Symbol
Dmel\AdhF-ChD
Species
D. melanogaster
Name
Fast Chateau Douglas
FlyBase ID
FBal0000317
Feature type
allele
Associated gene
Dmel\Adh
Associated Insertion(s)
Carried in Construct
Also Known As
AdhFChD
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Cytology
Description

Amino acid replacement: P214S.

(Eisses et al., 1994)

Amino acid replacement: K192T. Amino acid replacement: P214S.

(Eisses et al., 1990)

In addition to the K192T substitution, AdhF-ChD differs from AdhF by a synonymous mutation at nucleotide 816 (the T is characteristic of Slow alleles), insertion of a homopolymer repeat of 17 adenines, deletion of the 37bp length polymorphism at nucleotide 550-551 and a single site substitution at base 516 to a characteristic Slow nucleotide.

(Collet, 1988)

Nucleotide substitution: C1555T.

(Collet, 1988)

Amino acid replacement: K192T.

(Collet, 1988)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
M22210
AAA28338
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Mutant protein shows AdhS-like reaction kinetics and Km values.

    (Eisses et al., 1994)
    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer

    Lewis.

    Comments
    Comments

    pI of protein: 6.4 More thermostable than AdhF or AdhS.

    Amino acid replacement K192T alters protein concentration so it is similar to Slow protein levels. Amino acid replacement P214S gives thermostable substrate specificities and kinetic parameters similar to the Slow proteins.

    (Collet, 1988)

    AdhF-ChD was detected in 4 Chinese populations.

    (Jiang and Gibson, 1992)
    External Crossreferences and Linkouts ( 3 )
    Crossreferences
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Synonyms and Secondary IDs (5)
    Reported As
    Symbol Synonym
    Adh-FCh.D
    (Eisses et al., 1994)
    AdhF-ChD
    AdhFChD
    (Eisses et al., 1990, Collet, 1988)
    AdhI
    Name Synonyms
    Fast Chateau Douglas
    (Eisses et al., 1990)
    Secondary FlyBase IDs
      References (13)