FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Aprt5
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General Information
Symbol
Dmel\Aprt5
Species
D. melanogaster
Name
FlyBase ID
FBal0000688
Feature type
allele
Associated gene
Dmel\Aprt
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Johnson and Friedman, 1983)
Progenitor genotype
AprtB
(Johnson and Friedman, 1983)
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:1,884,051..1,884,051 [-]
Comment:

Single base deletion in Aprt leads to alteration of highly conserved residue S178 and a frameshift. Mutation identified in cDNA.

(Petitgas et al., 2024)
point_mutation
3L:1,884,444..1,884,444 [-]
Nucleotide change:

G1884444A

Reported nucleotide change:

G?A

Amino acid change:

R71Q | Aprt-PA; R71Q | Aprt-PC; R71Q | Aprt-PD

Reported amino acid change:

R?Q

Comment:

Mutation of conserved residue in Aprt. Mutation identified in cDNA sequence.

(Petitgas et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Lesch-Nyhan syndrome
      CEA
      (Petitgas et al., 2024)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Aprt5 is partially rescued by Scer\GAL4elav-C155/AprtUAS.cPa

      (Petitgas et al., 2024)
      Not rescued by

      Aprt5 is not rescued by AprtUAS.cPa/Scer\GAL4Eaat1.PR

      (Petitgas et al., 2024)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Selected as: Purine resistant by feeding.

      (Johnson and Friedman, 1983)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Aprt5
      (Petitgas et al., 2024, Stenesen et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)