FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\parabss2
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General Information
Symbol
Dmel\parabss2
Species
D. melanogaster
Name
FlyBase ID
FBal0001326
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: L1699F.

    (Parker et al., 2011)

    Coordinates of lesion are relative to the para-RA/para-PA sequence.

    (Parker et al., 2011)

    Nucleotide substitution: C5364T.

    (Parker et al., 2011)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:16,466,791..16,466,791 [-]
    Nucleotide change:

    C16466791T

    Reported nucleotide change:

    C16360824T

    Amino acid change:

    L1699F | para-PA; L1652F | para-PAA; L1654F | para-PAB; L1652F | para-PAC; L1654F | para-PAD; L1676F | para-PAE; L1678F | para-PAF; L1657F | para-PAG; L1675F | para-PAH; L1654F | para-PAI; L1700F | para-PAJ; L1665F | para-PAK; L1679F | para-PAL; L1651F | para-PAM; L1711F | para-PAN; L1681F | para-PAO; L1665F | para-PAP; L1657F | para-PAQ; L1635F | para-PAS; L1624F | para-PAT; L1630F | para-PAW; L1667F | para-PAX; L1700F | para-PAY; L1679F | para-PAZ; L1699F | para-PB; L1700F | para-PBA; L1634F | para-PBB; L1624F | para-PBD; L1699F | para-PBF; L1699F | para-PBG; L1623F | para-PBH; L1699F | para-PC; L1682F | para-PD; L1676F | para-PE; L1676F | para-PF; L1655F | para-PG; L1665F | para-PH; L1647F | para-PI; L1668F | para-PJ; L1644F | para-PK; L1655F | para-PL; L1668F | para-PM; L1668F | para-PN; L1660F | para-PO; L1689F | para-PP; L1644F | para-PQ; L1647F | para-PR; L1668F | para-PS; L1678F | para-PT; L1686F | para-PU; L1665F | para-PV; L1670F | para-PW; L1693F | para-PX; L1706F | para-PY; L1657F | para-PZ

    Reported amino acid change:

    L1699F

    Comment:

    Location reported as an R5 coordinate.

    (Parker et al., 2011)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Electroconvulsive stimulation delivered to the brain of bss1 flies reproducibly induces the bang-sensitive repertoire of seizure behaviour; such electroconvulsive seizures can actually be induced in wild-type flies but this requires more extreme stimulus intensities than for bss2 flies. The failure and recovery of the giant fibre (GF) pathway can be detected by recording the dorsal longitudinal muscle (DLM) physiological response. Following 1 Hz brain stimulation, bss2 mutants have a significantly longer period of DLM response failure, and have an increased sensitivity for induction of this response failure, compared to wild type. Additionally, the maximal initial discharge induction is shifted toward lower stimulus intensities in the mutant flies.

        (Lee and Wu, 2002)

        Bang sensitive paralytic mutant.

        (Ganetzky and Wu, 1982)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Phenotype suppressed by mlenap-ts1, even at permissive temperatures.

        (Ganetzky and Wu, 1982)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        bss2
        (Parker et al., 2011)
        bssPC75
        (Kulkarni et al., 1988)
        parabss2
        (Parker et al., 2011)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)