Yolk protein synthesis reduced approximately twenty fold in homozygous females; such females are also defective in the synthesis of larval-serum protein 2 (LSP2) although LSP2 synthesis in larvae is unaffected. Adult fat body normal in morphology and in other secretory functions. Larval fat body persists into adult stage; oocyte development arrested in previtellogenic stage. Methoprene, a juvenile hormone analogue, which stimulates fat-body synthesis of yolk and vitellogenesis in starved wild-type females, has no effect in clt¹ females; however, ovarian transplant experiments indicate that clt¹ females have sufficient JH concentrations to promote oogenesis. Ecdysone, on the other hand, stimulates LSP2 and yolk-protein synthesis in clt¹ females, but has no effect on larval-fat-body regression or oogenesis.