FB2026_02 , released June 18, 2026
Allele: Dmel\Cyp6a291C
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General Information
Symbol
Dmel\Cyp6a291C
Species
D. melanogaster
Name
FlyBase ID
FBal0002207
Feature type
allele
Associated gene
Dmel\Cyp6a2
Associated Insertion(s)
17.6{?'LTR}Cyp6a291C
Carried in Construct
Also Known As
Cyp6a2-91C, 91-C
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Waters et al., 1992)
Progenitor genotype
Associated Insertion(s)
17.6{?'LTR}Cyp6a291C
Cytology
Description

Nucleotide substitution: G1410?.

(Wan et al., 2014)

Compared to other alleles (notably Cyp6a291R), Cyp6a291C has a single nucleotide (G1410) deleted in the coding region - this shifts the downstream reading frame and creates a premature STOP codon. This mutant would putatively produce a C-truncated protein of 483 amino acids, which would lack the Cys residue which is the absolutely conserved amino acid functioning as the fifth ligand to the heme. The Cyp6a291C allele also has a 513-bp insertion of a 17.6 element in the 3' UTR.

(Wan et al., 2014)

A solitary long terminal repeat (LTR) of the 17.6 element is located in the 3' untranslated region. The LTR contains 513bp and is flanked by the 4bp repeated sequence ATAT.

(Waters et al., 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:6,780,023..6,780,023 [-]
Comment:

A one bp deletion causes a frameshift at amino acid 431 of Cyp6a2.

(Wan et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
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      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Characteristic of insecticide susceptible strains.

      External Data
      Interactions
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      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      91-C
      (Dombrowski et al., 1998, Waters et al., 1992)
      Cyp6a2-91C
      (Kuruganti et al., 2007, Maitra et al., 2000)
      Cyp6a291-C
      (Wan et al., 2014)
      Cyp6a291C
      Cyt-P450-B191C
      Name Synonyms
      Secondary FlyBase IDs
        References (7)