Mutant flies are arrhythmic for locomotor activity under constant light conditions at a constant temperature of 25[o]C, but become rhythmic after being exposed to a temperature cycle of 12 hours at 25[o]C and 12 hours at 30[o]C, showing a weak anticipatory activity. There is no peak at the early thermophase, while activity in the cryophase is considerably enhanced.
Flies are arrhythmic in constant darkness. Locomotor activity of flies in light-dark cycles demonstrates they manifest a morning activity peak in anticipation of lights-on and a larger evening activity peak anticipating lights-off. These activity profiles suggest the presence of an active pacemaker. This is confirmed by the shift in the phase of the evening activity peak in the presence of pers (shifted to an earlier time) and perL1 (shifted to a later time).
Viable. Adult eye and optic lobes have defects. The unconnected phenotype exhibits photoreceptors that degenerate with age, disorganized muscle tissue fills the space normally occupied by optic ganglia: flies are blind. The connected phenotype exhibits photoreceptor axons that innervate the optic ganglia, structure is disorganized and distinguishable from wild type. Extensive degeneration of photoreceptor cells becomes apparent in the form of dark spots on the compound eye.
reduced viability.
Steller.
