FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dl2
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General Information
Symbol
Dmel\dl2
Species
D. melanogaster
Name
FlyBase ID
FBal0002644
Feature type
allele
Associated gene
Dmel\dl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

heat sensitive hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

heat sensitive hypomorphic allele - genetic evidence

(Isoda et al., 1992)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Gly to Glu substitution at amino acid 68, within the amino terminal half.

(Isoda et al., 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:17,442,784..17,442,784 [-]
Nucleotide change:

G17442784A

Amino acid change:

G68E | dl-PA; G68E | dl-PB; G68E | dl-PC; G68E | dl-PD; G68E | dl-PE; G68E | dl-PF

Reported amino acid change:

G68E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Isoda et al., 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pupal lethal when heterozygous with the MBT chromosome.

      (Riede, 2001)

      Single cells from N55e11 embryos transplanted into the ventral neurogenic region of host embryos derived from dl2 mothers give rise to neural cells in 91% of cases.

      (Stüttem and Campos-Ortega, 1997)

      When in trans with Df(2L)TW119 the transgene P{Dipt2.2-lacZ} is not induced.

      (Lemaitre et al., 1995)

      Strong dorsalization at 22oC: loss of ventral epidermis.

      (Isoda et al., 1992)

      Embryos derived from dl2 mothers are incompletely dorsalised.

      (Schupbach and Wieschaus, 1989)

      Embryos derived from homozygous females are dorsalised.

      (Carroll et al., 1987)

      Double mutants N55e11 and Dl9P with dl2 had neuralization of additional ectodermal cells in the thoracic and abdominal segments. Double mutants N2 and N3 with dl2 gave slight neuralization of the cephalic epidermis.

      (Campos-Ortega, 1983)

      temperature-sensitive

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Df(3R)mbtP, dl2 has lethal | pupal stage phenotype

      (Riede, 2001)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Many of the melanotic nodules seen in cact7 dl2 double mutant larvae are of hematopoietic origin; they are located in the hemocoel and lymph glands and consist of large, flat F-actin-rich lamellocytes or both lamellocyte and plasmatocyte-like cells. Melanotic agglomerates containing different tissue types are not seen in the double mutants (in contrast to cact7 single mutants).

      (Minakhina and Steward, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dl2
      (Minakhina and Steward, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (11)