FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dl17
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General Information
Symbol
Dmel\dl17
Species
D. melanogaster
Name
FlyBase ID
FBal0002659
Feature type
allele
Associated gene
Dmel\dl
Associated Insertion(s)
Carried in Construct
Also Known As
dlPZ
Key Links
Genomic Maps

Allele class

heat sensitive hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

heat sensitive hypomorphic allele - genetic evidence

(Isoda et al., 1992)
Mutagen
ethyl methanesulfonate
(Schupbach and Wieschaus, 1989, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Arg to His substitution at amino acid 310, within the amino terminal half.

(Isoda et al., 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:17,441,860..17,441,860 [-]
Nucleotide change:

G17441860A

Amino acid change:

R310H | dl-PA; R310H | dl-PB; R310H | dl-PC; R310H | dl-PD; R310H | dl-PE; R310H | dl-PF

Reported amino acid change:

R310H

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Isoda et al., 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When in trans with Df(2L)TW119 the transgene P{Dipt2.2-lacZ} is not induced.

      (Lemaitre et al., 1995)

      Weak dorsalization at 18oC: deletion of mesoderm but some ventral and lateral epidermis forms. Strong dorsalization at 22oC: loss of ventral epidermis.

      (Isoda et al., 1992)

      Embryos derived from homozygous females are incompletely dorsalised at 29oC; a tube of dorsal cuticle is formed. These embryos usually form some Filzkorper material and a small piece of head skeleton. At 18oC, the embryos are much less dorsalised and form ventral setae.

      (Schupbach and Wieschaus, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dl17
      dlPZ
      (Bergmann et al., 1996, Lemaitre et al., 1995, Isoda et al., 1992, Schupbach and Wieschaus, 1989, Tearle and Nusslein-Volhard, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)