FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dppH47
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General Information
Symbol
Dmel\dppH47
Species
D. melanogaster
Name
FlyBase ID
FBal0003060
Feature type
allele
Associated gene
Dmel\dpp
Associated Insertion(s)
Carried in Construct
Also Known As
dppHin47
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Posakony et al., 1990, Irish and Gelbart, 1987)
Mutagen
gamma ray
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Irish and Gelbart, 1987)
Description

Deletion of approximately 300bp removing part of the open reading frame.

(Posakony et al., 1990)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos have denticle belts around their entire circumference. Dorsally derived head and tail structures are lost.

      (Wisotzkey et al., 1998)

      dppH47/Df(2L)DTD2 animals die during embryogenesis. dppH47/Df(2L)DTD2 clones are associated with abnormalities in the wing and notum. dppH47/Df(2L)DTD2 clones in the posterior compartment of the wing can develop into normal wing blade, but are not fully competent to form veins. The presence of a dppH47/Df(2L)DTD2 clone on either the dorsal or ventral surface where a vein would normally form is sufficient to disrupt the vein.

      (Posakony et al., 1990)

      Fail to complete germ band extension, die with strong ventralized phenotype and no dorsal derived epidermis.

      (St. Johnston et al., 1990)

      Homozygotes have a ventralized embryonic phenotype: normally ventral epidermal pattern elements are present ventrally and dorsally.

      (Irish and Gelbart, 1987)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Mutant phenotype could not be rescued by P element mediated transformation of a wild type copy of dpp.

      (Hoffmann and Goodman, 1987)

      Allele class: Hin

      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Clonal analysis shows that there is a localised requirement for dpp+ function along the anterior-posterior (A/P) compartment boundary of the developing wing primordium; normal wing development is solely dependent on dpp+ function in the anterior compartment cells that border the A/P compartment boundary of the wing imaginal disk.

      (Posakony et al., 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dppH47
      dppHin47
      (St. Johnston et al., 1990, Hoffmann and Goodman, 1987, Irish and Gelbart, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)