FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eaD4
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General Information
Symbol
Dmel\eaD4
Species
D. melanogaster
Name
FlyBase ID
FBal0003477
Feature type
allele
Associated gene
Dmel\ea
Associated Insertion(s)
Carried in Construct
Also Known As
ea84b
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Chasan and Anderson, 1989)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: G283S.

(Jin and Anderson, 1990)

Nucleotide substitution: G1050A.

(Jin and Anderson, 1990)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,330,029..15,330,029 [+]
Nucleotide change:

G15330029A

Reported nucleotide change:

G1050A

Amino acid change:

G283S | ea-PA; G152S | ea-PB

Reported amino acid change:

G283S

(Jin and Anderson, 1990)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos weakly ventralized.

      (Jin and Anderson, 1990)

      Incompletely penetrant phenotype: ventrolateral structures are expanded at the expensive of dorsal structures.

      (Chasan and Anderson, 1989)

      incomplete penetrance

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      eaD4 is a non-suppressor of partially lethal - majority die | recessive phenotype of cact7

      (Qiu et al., 1998)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The zygotic semi-lethality of cact7 homozygotes is not suppressed by eaD4.

      (Qiu et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ea84b
      (Qiu et al., 1998, Jin and Anderson, 1990, Chasan and Anderson, 1989, Tearle and Nusslein-Volhard, 1987)
      eaD4
      Name Synonyms
      Secondary FlyBase IDs
        References (4)