FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eaD8
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General Information
Symbol
Dmel\eaD8
Species
D. melanogaster
Name
FlyBase ID
FBal0003481
Feature type
allele
Associated gene
Dmel\ea
Associated Insertion(s)
Carried in Construct
Also Known As
ea20n
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Chasan and Anderson, 1989)
Mutagen
ethyl methanesulfonate
(Erdelyi and Szabad, 1989)
Progenitor genotype
Cytology
Description

Amino acid replacement: G131E.

(Jin and Anderson, 1990)

Nucleotide substitution: G595A.

(Jin and Anderson, 1990)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,329,510..15,329,510 [+]
Nucleotide change:

G15329510A

Reported nucleotide change:

G595A

Amino acid change:

G131E | ea-PA

Reported amino acid change:

G131E

(Jin and Anderson, 1990)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos laid by heterozygous females are either ventralised or lateralised. Embryos laid by eaD8/Df(3R)ea-5022rx1 females are markedly more elongated and have fewer denticle bands than embryos laid by eaD8/+ females. All embryos laid by eaD8/Df(3R)ea-5022rx1 females develop a lateralised head fold during gastrulation.

      (Chang and Morisato, 2002)

      Embryos are lateralized and exhibit an almost apolar phenotype in which laterally derived denticles develop all around the embryo circumference. Perivitelline fluid transplantation using eaD8 embryos as donors and ea1/ea2 embryos as recipients demonstrated that the rescue of the ea phenotype results from the transplantation of the ea gene product.

      (Stein and Nusslein-Volhard, 1992)

      Embryos lateralized.

      (Jin and Anderson, 1990)

      Embryos have a lateralized phenotype: differentiate rings of ventral denticles around the entire dorso-lateral circumference and do not form the ventrally derived mesoderm.

      (Chasan and Anderson, 1989)

      Female viability and male fertility are not reduced. Embryos exhibit ventralised phenotype.

      (Erdelyi and Szabad, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      ea20n
      (Chang and Morisato, 2002, Jin and Anderson, 1990, Chasan and Anderson, 1989)
      eaD20m
      (Erdelyi and Szabad, 1989)
      eaD20n
      (Stein and Nusslein-Volhard, 1992)
      eaD8
      Name Synonyms
      Secondary FlyBase IDs
        References (5)