FB2025_05 , released December 11, 2025
Allele: Dmel\Egfrf10
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General Information
Symbol
Dmel\Egfrf10
Species
D. melanogaster
Name
FlyBase ID
FBal0003538
Feature type
allele
Associated gene
Dmel\Egfr
Associated Insertion(s)
Carried in Construct
Also Known As
top3B92, flb3B92
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Clifford and Schupbach, 1989, Schejter and Shilo, 1989)
Mutagen
ethyl methanesulfonate
(Clifford and Schupbach, 1994, Clifford and Schupbach, 1989, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T1318A. Amino acid replacement: C317S.

(Clifford and Schupbach, 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:21,555,760..21,555,760 [+]
Nucleotide change:

T21555760A

Reported nucleotide change:

T1318A

Amino acid change:

C317S | Egfr-PA; C366S | Egfr-PB

Reported amino acid change:

C317S

(Clifford and Schupbach, 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Enhances the female sterility and adult morphological defects of Egfrt1. Rarely survives as transheterozygote with the semi-viable Egfrtop-CA allele.

      (Clifford and Schupbach, 1994)

      Severe embryonic phenotype. Shows a rough eye phenotype in combination with EgfrE1.

      (Raz et al., 1991)

      Homozygotes and hemizygotes display a severe 'flb' phenotype. Embryos produced from heteroallelic combination with Egfrt1 have a severe ventralised phenotype, reduction in size of their dorsal appendage.

      (Clifford and Schupbach, 1989)

      severe allele

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: Embryonic lethal.

      Comments
      Comments

      Mutation of Egfr that coordinately affects all gene activities, a class I lesion. The allelic series for class I lesions: Egfrt2 = Egfrt1 < Egfrtop-EC20 < Egfrf7 = Egfrf1 = Egfrflb-2E07 < Egfrtop-EE39 = Egfrtop-ED26 = Egfrf5 < Egfrf9 = Egfrf10 = Egfrf2 = Egfrtop-EE42 = Egfrf11 = Egfrf24 = Egfrf3 = Df(2R)Egfr3.

      (Clifford and Schupbach, 1989)

      Class I allele.

      (Clifford and Schupbach, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Egfrf10
      flb
      flb3B92
      (Raz et al., 1991, Pawson and Bernstein, 1990, Schejter and Shilo, 1989)
      flbIIIB92
      (Tearle and Nusslein-Volhard, 1987)
      top3B92
      (Clifford and Schupbach, 1994, Clifford and Schupbach, 1989)
      Name Synonyms
      faint little ball
      Secondary FlyBase IDs
        References (7)