FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ether-resistant1
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General Information
Symbol
Dmel\Ether-resistant1
Species
D. melanogaster
Name
FlyBase ID
FBal0003882
Feature type
allele
Associated gene
Ether-resistant
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
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    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
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    UniProtKB/Swiss-Prot
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        Expression Data
        Reporter Expression
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        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
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        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Flies are hypersensitive to γ-ray knockdown and lethality.

        (Gamo et al., 1990)

        More resistant than usual to killing effects of ether vapors administered to adults.

        External Data
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        Show genetic interaction network for Enhancers & Suppressors
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        Mutant
        Wild-type
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        Notes on Origin
        Discoverer

        Selected as: Strain produced by 29 generations of selection.

        Comments
        Comments

        Eth1-bearing strain also relatively resistant to killing effects of chloroform or halothane; these phenotypes are dominant and semidominant, respectively; chloroform resistance due to major factor on chromosome 1 and a minor one on chromosome 2; halothane resistance caused by major factor on third chromosome (not known if same locus as that responsible for most of the ether resistance) and minor components on chromosomes 1 and 2; halothane resistance also seen with respect to anesthesia and genetic difference for this maps to chromosome 1.

        Eth1 is the major determinant for resistance to ether lethality in the ether resistant Eth-29 strain (minor factors are present on chromosome 1). Resistance to ether lethality is dominant. The Eth-29 also shows incompletely dominant resistance to halothane lethality due to a major determinant on chromosome 3, and minor factors on chromosomes 1 and 2. The relationship between the chloroform resistance determinant on chromosome 3 and Eth1 is unclear. The lipid composition of wild-type and Eth-29 flies carrying Eth1 has been analysed.

        (Gamo et al., 1982)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Eth-29
        (Gamo et al., 1990)
        Eth1
        Ether-resistant1
        Name Synonyms
        Secondary FlyBase IDs
          References (3)