FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fcl1
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General Information
Symbol
Dmel\fcl1
Species
D. melanogaster
Name
FlyBase ID
FBal0003993
Feature type
allele
Associated gene
fcl
Associated Insertion(s)
Carried in Construct
Also Known As
fcl244b
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Eberl et al., 1992, Eberl and Hilliker, 1988)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos exhibit dorsal closure defects. Amplitude and other transmission characteristics of the neuromuscular junction are not significantly different from wild type.

      (Broadie et al., 1997)

      Malpighian tubules are variable in diameter in homozygous embryos.

      (Harbecke and Lengyel, 1995)

      Embryos exhibit failure of dorsal closure and a weak cuticle.

      (Broadie and Bate, 1993, Broadie and Bate, 1993)

      Large dorsal yolk plug, no cuticle and segment defects.

      (Eberl and Hilliker, 1988)

      embryonic lethal central yolk plug; dorsal closure may be incomplete; head involution partial; germ band contraction incomplete. No cuticle evident in cuticle preparations, but mouth parts and spiracles visible. Embryos exhibit considerable movement. no internal organogenesis; prominent

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      EH244b
      (Eberl et al., 1992)
      fcl1
      fcl244b
      (Broadie et al., 1997, Broadie and Bate, 1993, Broadie and Bate, 1993)
      fclEH244b
      (Harbecke and Lengyel, 1995)
      l(1)EH244b
      (Eberl and Hilliker, 1988)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0031263
      References (6)