FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fkh2
Open Close
General Information
Symbol
Dmel\fkh2
Species
D. melanogaster
Name
FlyBase ID
FBal0004008
Feature type
allele
Associated gene
Dmel\fkh
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Weigel et al., 1989)
Mutagen
ethyl methanesulfonate
(Weigel et al., 1989, Jurgens and Weigel, 1988, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

17bp deletion accompanied by a 2bp insertion: mutant protein lacks six amino acids that are replaced by a different one.

(Weigel et al., 1989)

in-frame deletion of codons 233-237; 17 bp deletion + 2 bp insertion

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:28,583,843..28,583,859 [-]
Comment:

A 17bp deletion accompanied by a 2bp insertion beginning in amino acid 232; 6 amino acids of wild type fkh protein are replaced with Ile.

Inserted_sequence:

TC

(Weigel et al., 1989)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Failure of head involution. Homeotic transformations in the pre-oral head region and the foregut. Posterior tail region and the hindgut are homeotically replaced by anterior tail and post-oral head. Embryos lack oesophagus, proventriculus, hindgut and Malpighian tubules.

      (Jurgens and Weigel, 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      fkh2
      Name Synonyms
      Secondary FlyBase IDs
        References (4)