Deposition of electron-dense material in nucleus and cytoplasm of fat cells begins during pupal stage; pericardial cells of adult become filled with electron-opaque granules and vacuoles.
Pupa and young fly characterized by accumulation of dark pigment; in older fly, pigment becomes concentrated in black specks scattered through body, head, and legs. RK2.
The occasional weak manifestation of the Frd1 phenotype transmitted from Cy1/Frd1 males to their Cy1 offspring suggests an extrachromosomal component of the Frd1 phenotype.