FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SxlK1274-1
Open Close
General Information
Symbol
Dmel\SxlK1274-1
Species
D. melanogaster
Name
FlyBase ID
FBal0004305
Feature type
allele
Associated gene
Dmel\Sxl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Previously the females were described as having severely atrophied ovaries at 29oC and at 23oC females are fertile (FBrf0039483). Now females are sterile between 18oC and 29oC. SxlK1274-1/Sxlf1 individuals are lethal. Double homozygous snf- SxlK1274-1 females are semi-lethal and survivors have tumorous egg chambers.

      (Sugimura et al., 1994)

      At the non-permissive temperature homozygous females lay no eggs.

      (Perrimon and Gans, 1983)

      females produce few if any eggs. temperature-sensitive recessive female-sterile Viability good at 29oC but ovaries of homozygous females severely atrophied, probably with tumorous follicles. At 25oC cysts contain 16 nurse cells and no oocyte; females fertile when raised at 23oC. Mosaic studies indicate germ-line function of gene (Perrimon and Gans, 1983).

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SxlK1274-1
      fs(1)K1274
      (Perrimon and Gans, 1983)
      fs(1)K12741
      Name Synonyms
      Secondary FlyBase IDs
        References (2)