FlyBase Allele Report: Dmel\fu[54]

General Information

Symbol

Dmel\fu⁵⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0004887

Feature type

allele

Associated gene

Dmel\fu

Associated Insertion(s)

Carried in Construct

Also Known As

fu^M1

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

diepoxybutane

Nature of the Allele

Allele class

Mutagen

diepoxybutane

(Therond et al., 1996, Preat et al., 1993, Busson et al., 1988)

Progenitor genotype

Cytology

Description

28bp deletion of genomic sequences 1216-1243, only the first 80 amino acids are present followed by 15 new amino acids.

(Therond et al., 1996)

28-bp deletion.

(Preat, 1994.9.22)

28bp deletion in the kinase domain. Class II fu allele, affects the carboxy domain of the protein by changing the open reading frame in the 5' region.

(Preat et al., 1993)

30bp deletion within putative kinase domain.

(Preat et al., 1990)

28bp deletion

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:18,658,152..18,658,179 [+]

Comment:

28bp deletion

(Preat et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased fecundity

(Busson et al., 1988)

lethal

(Busson et al., 1988)

visible

(Claret et al., 2007, Busson et al., 1988)

Phenotype Manifest In

first posterior wing cell

(Claret et al., 2007)

wing vein

(Busson et al., 1988)

Detailed Description

Statement

Reference

Flies show fusion of longitudinal wing veins 3 and 4 and narrowing of the L3-L4 intervein region.

(Claret et al., 2007)

strong wing phenotype - veins L3 and L4 fused all along length; strong viability phenotype - ratio of the number of fused flies to wild type in fu/+ X fu/Y is 0.25-0.5; intermediate fecundity phenotype - ratio of eggs laid by fu/fu versus fu/+ sisters is 0.25-0.5; strong maternal effect on segmentation - percent of embryos with all segments entirely duplicated is 70-100%.

(Busson et al., 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

fu⁵⁴ has phenotype, enhanceable by Su(fu)^LP

(Preat et al., 1993)

Suppressor of

Statement

Reference

fu⁵⁴ is a suppressor of wing cell phenotype of Scer\GAL4^71B, smo^ΔFU.UAS

(Malpel et al., 2007)

Other

Statement

Reference

Su(fu)^LP, fu⁵⁴ has wing phenotype

(Preat et al., 1993)

Su(fu)^LP, fu⁵⁴ has leg phenotype

(Preat et al., 1993)

Su(fu)^LP, fu⁵⁴ has haltere phenotype

(Preat et al., 1993)

Su(fu)^LP, fu⁵⁴ has wing blade anterior compartment phenotype

(Preat et al., 1993)

Su(fu)^LP, fu⁵⁴ has leg anterior compartment phenotype

(Preat et al., 1993)

Su(fu)^LP, fu⁵⁴ has haltere anterior compartment phenotype

(Preat et al., 1993)

Additional Comments

Genetic Interactions

Statement

Reference

When in combination with Su(fu)^LP or cos³ heterozygotes individuals die as pupae. Adult escapers display wings, halteres and legs that have duplication of structures in the anterior compartment and shortening along the proximal-distal axis. Embryos derived from heterozygotes with Su(fu) mutants display a segment polarity phenotype: thoracic denticle belts are absent, last two rows of abdominal denticle belts are absent and a mirror image duplication of anterior rows of abdominal denticle belts.

(Preat et al., 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

fu⁵⁴ is partially rescued by fu^{UAS.Tag:Palm(hGAP43),CFP}/Scer\GAL4^Bx-MS1096

(Claret et al., 2007)

fu⁵⁴ is partially rescued by Scer\GAL4^71B/fu^{UAS.Tag:Palm(hGAP43),CFP}

(Claret et al., 2007)

Comments

Expression of fu^{Scer\UAS.T:Hsap\Myr2,T:Avic\GFP-CFP} under the control of either Scer\GAL4^Bx-MS1096 or Scer\GAL4^71B rescues the reduction in the L3-L4 intervein region that is seen in fu⁵⁴ flies, although the rescued wings show some wing vein abnormalities.

(Claret et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

7206

fu⁵⁴/FM6

Notes on Origin

Discoverer

Comments

Class II mutation based on interaction with Su(fu)^LP, suppression of embryonic and adult phenotype but display an additional phenotype.

(Therond et al., 1996)

External Crossreferences and Linkouts ( 2 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

S69164

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAB29839

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fu⁵⁴

(Chang et al., 2013, Cheng et al., 2012)

fu^M1

(Han et al., 2025, Zhou and Kalderon, 2011, Claret et al., 2007, Malpel et al., 2007, Therond et al., 1996, Preat et al., 1993, Preat et al., 1990, Busson et al., 1988)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

Open Close