FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Got2nJ
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General Information
Symbol
Dmel\Got2nJ
Species
D. melanogaster
Name
FlyBase ID
FBal0005131
Feature type
allele
Associated gene
Dmel\Got2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Chase and Kankel, 1987)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        larval neuromuscular junction & postsynaptic membrane (with Got21)

        (Augustin et al., 2007)
        Detailed Description
        Statement
        Reference

        Got2nJ/Got21 larval neuromuscular junctions show a large increase in postsynaptic glutamate receptor number.

        (Augustin et al., 2007)

        The amplitude of glutamate-gated currents is increased in mutant embryos compared to wild-type (2459 +/- 215 pA compared to 1691 +/- 71 pA), when glutamate is pressure-ejected onto the postsynaptic neuromuscular junction. Single-channel current amplitude of postsynaptic glutamate receptors is not different from wild type in the mutant embryonic neuromuscular junction. The amplitude of spontaneous excitatory junctional currents is increased in the mutant embryonic neuromuscular junction compared to wild type (268 +/- 72 pA compared to 141 +/- 14 pA).

        (Featherstone et al., 2002)

        Anodal migration is probably equal to Got21.

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (2)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Got2nJ
        Got2nJH385
        got2nj
        (Augustin et al., 2007, Featherstone et al., 2002)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)