FlyBase Allele Report: Dmel\hry[25]

General Information

Symbol

Dmel\hry²⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0005342

Feature type

allele

Associated gene

Dmel\hry

Associated Insertion(s)

Carried in Construct

Also Known As

h^5H07, h²⁵

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Howard and Ingham, 1986)

Mutagen

ethyl methanesulfonate

(Wainwright and Ish-Horowicz, 1992, Hooper et al., 1989, Tearle and Nusslein-Volhard, 1987, Ingham et al., 1985)

Progenitor genotype

hry¹

(Wainwright and Ish-Horowicz, 1992, Tearle and Nusslein-Volhard, 1987, Ingham et al., 1985)

Cytology

Polytene chromosomes normal.

(Ingham et al., 1985)

Description

Amino acid replacement: E40V. In the basic domain. Nucleotide substitution: A?T.

(Wainwright and Ish-Horowicz, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:8,677,391..8,677,391 [+]

Nucleotide change:

A8677391T

Reported nucleotide change:

A?T

Amino acid change:

E40V | hry-PA; E40V | hry-PB

Reported amino acid change:

E40V

(Wainwright and Ish-Horowicz, 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

lethal | recessive

(Ma et al., 1996, Wainwright and Ish-Horowicz, 1992, Hooper et al., 1989, Howard and Ingham, 1986, Ingham et al., 1985)

Phenotype Manifest In

embryonic labial segment

(Rusch and Kaufman, 2000)

larval abdominal segment 2

(Ingham et al., 1985)

larval abdominal segment 4

(Ingham et al., 1985)

larval abdominal segment 6

(Ingham et al., 1985)

larval abdominal segment 8

(Ingham et al., 1985)

larval midgut & embryo & epidermis

(Harbecke and Lengyel, 1995)

presumptive embryonic salivary gland

(Myat and Andrew, 2002)

presumptive embryonic salivary gland (with hry⁶⁷⁴)

(Myat and Andrew, 2002)

ventral denticle belt

(Ingham et al., 1985)

wing & macrochaeta & adult

(Rushlow et al., 1989)

Detailed Description

Statement

Reference

Homozygous embryos have abnormally shaped salivary glands; 7% have elongated, expanded lumens and 93% have short, expanded lumens (wild-type salivary glands have elongated, unbranched lumens). h²⁵/h⁶⁷⁴ embryos have salivary glands with either branched or expanded lumens.

(Myat and Andrew, 2002)

The labial lobe is absent in mutant embryos.

(Rusch and Kaufman, 2000)

Degeneration of the midgut epithelium is seen in homozygous embryos.

(Harbecke and Lengyel, 1995)

The phenotype of fu⁴¹ h²⁵ double mutants can be interpreted as an addition of the corresponding single mutant phenotypes, except that the naked cuticle of segments A5 and A7 which is absent in the h²⁵ single mutant, is replaced by a mirror duplication of the remaining denticle belts in the fu h double mutant.

(Limbourg-Bouchon et al., 1991)

"Pair-rule segmentation phenotype": half the normal number of denticle bands form, due to a deletion of pattern elements from approximately the middle of one segment to a homologous position in the next segment.

(Howard and Ingham, 1986)

The denticle belts associated with the A3/4 and A5/6 composite segments are often fused in homozygous larvae and they may show a more extreme phenotype, resulting in a continuous lawn of denticles throughout the abdomen. Fails to complement the bristle phenotype of h¹.

(Ingham et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

hry²⁵ is a non-enhancer of lethal | embryonic stage | maternal effect phenotype of Gug^unspecified

(Zhang et al., 2002)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

hry⁴¹/hry²⁵ is partially rescued by hry^cosh

(Rushlow et al., 1989)

Comments

The segmentation defect of heterozygote h²⁵/h⁴¹ can be rescued by h^cosh and individuals develop to viable adults, but the strong bristle phenotype is still present.

(Rushlow et al., 1989)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

1781

ru¹ hry²⁵ Diap1^th-1 st¹ cu¹ sr¹ e^s ca¹/TM3, Sb¹

Kyoto

106503

ru¹ hry²⁵ Diap1^th-1 st¹ cu¹ sr¹ e^s ca¹/TM3, Sb¹

Notes on Origin

Discoverer

Jurgens.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

h²⁵

(Schroeder et al., 2011, Zhai et al., 2009)

h^5H07

(Zhang et al., 2002, Nagel and Preiss, 1999, Ma et al., 1996, Colas et al., 1995, Harbecke and Lengyel, 1995, Limbourg-Bouchon et al., 1991, Hooper et al., 1989, Rushlow et al., 1989, Hiromi and Gehring, 1987, Howard and Ingham, 1986, Ingham et al., 1985)

h^5H

(Wainwright and Ish-Horowicz, 1992, Tearle and Nusslein-Volhard, 1987)

h^5h07

(Joshi et al., 2006, Orenic et al., 1993)

hry²⁵

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

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