FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hry31
Open Close
General Information
Symbol
Dmel\hry31
Species
D. melanogaster
Name
FlyBase ID
FBal0005348
Feature type
allele
Associated gene
Dmel\hry
Associated Insertion(s)
Carried in Construct
Also Known As
h14H
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wainwright and Ish-Horowicz, 1992, Hooper et al., 1989, Tearle and Nusslein-Volhard, 1987, Ingham et al., 1985)
Progenitor genotype
Caused by aberration
In(3LR)h31
Cytology

Polytene chromosomes normal.

(Ingham et al., 1985)
Description

Nucleotide substitution: C?T. Amino acid replacement: R46C. Mutation is in the first amphipathic helix of the HLH domain.

(Wainwright and Ish-Horowicz, 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:8,677,408..8,677,408 [+]
Nucleotide change:

C8677408T

Reported nucleotide change:

C?T

Amino acid change:

R46C | hry-PA; R46C | hry-PB

Reported amino acid change:

R46C

(Wainwright and Ish-Horowicz, 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h25, and fails to complement the bristle phenotype of h1.

      (Ingham et al., 1985)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Has no effect on the eye phenotype produced by activated arm constructs. (either armS44Y.GMR or armS56F.GMR).

      (Freeman and Bienz, 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Nusslein-Volhard.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      h14H107
      (Ingham et al., 1985)
      h14H
      (Freeman and Bienz, 2001, Wainwright and Ish-Horowicz, 1992, Tearle and Nusslein-Volhard, 1987)
      h14N107
      (Hooper et al., 1989)
      h31
      hry31
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0045830
      References (6)