FlyBase Allele Report: Dmel\l(1)10Bh[3ms]

General Information

Symbol

Dmel\l(1)10Bh^3ms

Species

D. melanogaster

Name

FlyBase ID

FBal0006034

Feature type

allele

Associated gene

l(1)10Bh

Associated Insertion(s)

Carried in Construct

Also Known As

ms(1)v22

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Geer et al., 1983)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile

(Dybas et al., 1983)

female sterile

(Geer et al., 1983)

male semi-sterile

(Dybas et al., 1983)

male sterile

(Zhimulev et al., 1987, Geer et al., 1983)

partially lethal

(Dybas et al., 1983)

Phenotype Manifest In

primary spermatocyte cyst

(Dybas et al., 1983)

spermatid

(Dybas et al., 1983)

Detailed Description

Statement

Reference

Semilethal: 30% of viability.

(Zhimulev et al., 1987)

The divisions of the gonial cells are not completed in hemizygous males. Many primary spermatocyte cysts contain less than 16 cells. The spermatocyte nuclei are fenestrated in some areas, the nucleolus is large and the endoplasmic reticulum is closely associated with the nuclear envelope which is irregular. No normal mitochondrial derivatives are seen. Complete axonemes are seen in cells approximating stage 6, but the axonemes are not associated with normal membranes or mitochondria. Gametes degenerate in the spermatid stage.

(Dybas et al., 1983)

Mutation blocks gene functions that are critical to the development of both reproductive and non-reproductive tissues. Genetic lesions evident prior to meiosis in the male gametes.

(Geer et al., 1983)

viable male-sterile

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

MSV22

(Geer et al., 1983)

l(1)10Bh^3ms

l(1)GLM21^msv22

(Zhimulev et al., 1987)

ms(1)v22

(Dybas et al., 1983, Geer et al., 1983)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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