FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Lim31
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General Information
Symbol
Dmel\Lim31
Species
D. melanogaster
Name
FlyBase ID
FBal0008648
Feature type
allele
Associated gene
Dmel\Lim3
Associated Insertion(s)
Carried in Construct
Also Known As
lim3Bd1
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Nucleotide substitution: T604A. Amino acid replacement: C?S. Mutation falls in the second LIM domain. The C functions in the coordination of Zn ions and is conserved in all known LIM domains.

(Thor et al., 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,081,669..19,081,669 [-]
Nucleotide change:

T19081669A

Reported nucleotide change:

T604A

Amino acid change:

C104S | Lim3-PA; C184S | Lim3-PB; C184S | Lim3-PC; C184S | Lim3-PD; C69S | Lim3-PE; C184S | Lim3-PF; C184S | Lim3-PG

Reported amino acid change:

C?S

(Thor et al., 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In mutants, all Lim3 expressing interneurons and motor neurons show pathfinding defects. Muscles 6, 7, 12, 13, 14, 28 and 30 are not properly innervated. ISNb motor neurons maybe ectopically projecting into the ISNd target area.

      (Thor et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Wright.

      Comments
      Comments

      Strong allele.

      (Thor et al., 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Bd1
      (Thor et al., 1999)
      Lim31
      (Wang et al., 2024, Roshina and Pasyukova, 2007, Jordan et al., 2006)
      l(2)285
      l(2)37Bd1
      (Stathakis et al., 1995)
      lim3Bd1
      (Certel and Thor, 2004, Thor et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)