FlyBase Allele Report: Dmel\mago[SHL1]

General Information

Symbol

Dmel\mago^SHL1

Species

D. melanogaster

Name

FlyBase ID

FBal0009124

Feature type

allele

Associated gene

Dmel\mago

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

202bp deletion causing an N-terminal truncation.

(Newmark and Boswell, 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Newmark et al., 1997)

Phenotype Manifest In

fusome | germline clone

(Parma et al., 2007)

Detailed Description

Statement

Reference

Homozygous germline clones in adult females contain spectrosome-containing, putative germline stem cells (GSCs) in region 1 of the germarium, as occurs in wild type. However, regions 1, 2 and 3 of the mutant germaria lack branched fusomes and are instead populated with predominantly individual germline cells containing a spectrosome-like organelle (which is larger than that of a GSC). The mutant germline cells containing these spectrosome-like organelles become encapsulated by follicle cells and bud off from the germarium, forming forming pseudo-egg chambers. Clones induced at the larval stage or in adult females result in the same phenotype.

Homozygous somatic stem cells in the ovary divide and differentiate, producing stage 1-9 egg chambers that are indistinguishable from wild type.

(Parma et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mago^SHL1 has lethal phenotype, suppressible by Cele\mag-1^mago.PN

(Newmark et al., 1997)

Other

Statement

Reference

Cele\mag-1^mago.PN, mago^SHL1 has viable phenotype

(Newmark et al., 1997)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Female germline clones that are doubly mutant for tsu^Δ3-5 and mago^SHL1 have a phenotype indistinguishable from that of mago^SHL1 single mutant clones.

(Parma et al., 2007)

Xenogenetic Interactions

Statement

Reference

Two copies of Cele\mag-1^mago.PN are necessary to rescue the lethality of mago^SHL1.

(Newmark et al., 1997)

Complementation and Rescue Data

Rescued by

mago^SHL1 is rescued by mago^GFP

(Newmark et al., 1997)

mago^SHL1 is rescued by mago^Tag:MYC

(Newmark et al., 1997)

mago^SHL1 is rescued by mago^+t2.2

(Newmark and Boswell, 1994)

Partially rescued by

mago^SHL1 is partially rescued by mago^1.Tag:MYC

(Newmark et al., 1997)

Comments

Zygotic lethality is rescued by mago^{+t2.2.T:Hsap\MYC}, mago^{+t2.2.T:Avic\GFP} and mago^1.T:Hsap\MYC. mago^SHL1 homozygous females carrying mago^1.T:Hsap\MYC give rise to sterile progeny.

(Newmark et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Boswell.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

SHL-1

(Newmark et al., 1997)

l(2)57Ca²

l(2)SHL1

mago^SHL-1

(Parma et al., 2007)

mago^SHL1

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close