FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\l(2)mbn1
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General Information
Symbol
Dmel\l(2)mbn1
Species
D. melanogaster
Name
FlyBase ID
FBal0009284
Feature type
allele
Associated gene
l(2)mbn
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Gateff, 1977)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lethal at the time of puparium formation. The number of free blood cells in the hemolymph of the mature larva is 35-40 times that of wild-type due to the continuous and uncontrolled production of immature phagocytic blood cells by the hematopoietic organs. Most free blood cells resemble plasmatocytes, podocytes are rarely observed. Crystal cells are present in reduced numbers. A few blood cells are sickle-shaped. The lymph glands are enlarged up to 3000 times that of wild-type. Larval tissues, such as the imaginal discs, fat body and muscles are destroyed by invasion and phagocytosis. No encapsulation or melanisation of larval tissue takes place.

      (Gateff, 1977)

      Hyperplasia of cellular components of larval hemolymph; cell counts 30-40 times normal; cells resemble immature plasmatocytes. In premortal stages the larval tissues have mostly disintegrated and larvae appear to be sacks filled with blood cells. Cells do not proliferate when transplanted to normal larvae.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Used l(2)mbn mutant cell line from A.Dorn.

      (Dorstyn et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      l(2)mbn
      (Gateff, 1977)
      l(2)mbn1
      mbn-2
      (Kappler et al., 1993)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)