FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\nbs2
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General Information
Symbol
Dmel\nbs2
Species
D. melanogaster
Name
nbs2
FlyBase ID
FBal0009780
Feature type
allele
Associated gene
Dmel\nbs
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Nucleotide substitution: C2113T.

(Oikemus et al., 2006)

Amino acid replacement: Q685term.

(Oikemus et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:9,720,931..9,720,931 [-]
Nucleotide change:

C9720931T

Reported nucleotide change:

C2113T

Amino acid change:

Q689term | nbs-PD; Q691term | nbs-PE

Reported amino acid change:

Q685term

Comment:

The annotation and thus the amino acid sequence of nbs has changed over time. The site of the mutation was deduced from the genomic sequence surrounding the mutation site reported in FBrf0194327.

(Oikemus et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      nbs1/nbs2 mutant flies die as pharate adults with rough eyes and missing or abnormal bristles.

      nbs2 mutant cells exhibit DNA breaks and telomere fusions in metaphase and anaphase.

      (Oikemus et al., 2006)

      Lethal phase is during the pupal to adult stages.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Leicht.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      l(3)67BDr1
      l(3)e97C2
      nbs2
      Name Synonyms
      nbs2
      (Oikemus et al., 2006)
      Secondary FlyBase IDs
        References (2)