FlyBase Allele Report: Dmel\mei-218[6-7]

General Information

Symbol

Dmel\mei-218^6-7

Species

D. melanogaster

Name

FlyBase ID

FBal0012140

Feature type

allele

Associated gene

Dmel\mei-218

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle

(Bickel et al., 2002, McKim et al., 1996, Carpenter and Baker, 1982)

Phenotype Manifest In

cell cycle

(Bickel et al., 2002)

oocyte

(Bickel et al., 2002)

Detailed Description

Statement

Reference

Almost all oocytes from mei-218^6-7 homozygous mothers fail to arrest at metaphase I. No defects are seen in sister chromatid cohesion.

(Bickel et al., 2002)

Crossing over frequency is reduced compared to wild type. Reduction in crossing over is twofold less in the centromere proximal regions compared to the distal regions. High levels of nondisjunction on the X chromosome, lower levels on the 4th chromosome.

(McKim et al., 1996)

Reduces meiotic exchange.

(Carpenter and Baker, 1982)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement