FlyBase Allele Report: Dmel\mei-41[A1]

General Information

Symbol

Dmel\mei-41^A1

Species

D. melanogaster

Name

FlyBase ID

FBal0012168

Feature type

allele

Associated gene

Dmel\mei-41

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle

(Smith, 1976)

chemical sensitive | semidominant

(Smith, 1976)

female semi-sterile

(Laurencon et al., 2003)

female sterile | recessive

(Smith, 1976)

radiation sensitive

(Smith, 1976)

viable

(Laurencon et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

Hemizygous male larvae are sensitive to methyl methanesulfonate (MMS). They show sensitivity to ultra violet (UV) light and X rays. Sensitivity to MMS is recessive at 0.075% MMS and shows a strong semidominant effect at 0.125% MMS. Only 3.3% of eggs laid by homozygous females develop into adults that eclose. mei-41^A1 mus102^A1 double mutant larvae have a greatly increased sensitivity to MMS compared to either single mutant. An increase compared to wild type in X chromosome loss due to non-disjunction is seen in the progeny of homozygous females.

(Smith, 1976)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

(Smith, 1976)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Fails to complement: mus102^A2. Fails to complement: mus102^A3. Fails to complement: mus102^A4. Fails to complement: mus102^A5. Fails to complement: mus102^A6. Fails to complement: mus102^A7. Fails to complement: mus102^A8.

(Smith, 1976)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

mei-41^A1-A17

mei-41^A1

mei-41^D17

mut^s

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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