FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mei-9L1
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General Information
Symbol
Dmel\mei-9L1
Species
D. melanogaster
Name
FlyBase ID
FBal0012180
Feature type
allele
Associated gene
Dmel\mei-9
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Yildiz et al., 2004)
Progenitor genotype
Cytology
Description

Deletion of nucleotides 721-759, resulting in an in frame deletion of amino acid residues 199-210.

(Yildiz et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mei-9L1/mei-9A2 females show 37% X chromosome nondisjunction, compared to 0.33% in wild-type females. mei-9L1/mei-9A2 larvae are hypersensitive to ultraviolet light and nitrogen mustard.

      (Yildiz et al., 2004)

      mei-9L1 males show a lower frequency of crossing-over in the germ cells induced by larval feeding of 5-azacytidine or mitomycin C than wild-type males.

      (Pontecorvo et al., 1992)

      Reduces exchange.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The eye phenotype caused by expression of DDB1dsRNA.650.Scer\UAS under the control of Scer\GAL4ey.PH is not affected by mei-9L1/+.

      (Takata et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Graf et al.

      Comments
      Comments

      An endonuclease activity which is specific for partially depurinated DNA is reduced in extracts of mei-9L1 larval brain ganglia compared to wild-type.

      (Osgood and Boyd, 1982)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      mei-9L1
      mus9L1
      (Vogel and Nivard, 1997)
      mut159
      Name Synonyms
      Secondary FlyBase IDs
        References (12)