FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Zw1015
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General Information
Symbol
Dmel\Zw1015
Species
D. melanogaster
Name
FlyBase ID
FBal0012304
Feature type
allele
Associated gene
Dmel\Zw10
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Smith et al., 1985)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Brain cells are hyperploid. Aneuploidy involves improper chromosome segregation at anaphase: precocious sister chromatid separation. Mitotic index and the ratio of numbers of cells in anaphase relative to the total number of mitotic figures in larval brains is similar in wild type. Lethal phenotype can be rescued by P element mediated transformation of a wild type mit(1)15 gene copy.

      (Williams et al., 1992)

      Chromosome behaviour in the wing and abdominal cells is abnormal; an increased frequency of homozygous mwh- clones is seen in the wings of mit(1)1515/Y;mwh-/+ males, and an increased frequency of y- mwh- twin spots in the abdomen of mit(1)1515/Y;T(1;3)scJ4, y+ mwh-/+ males. A high frequency of larval neuroblasts are hyperploid for one or more chromosomes.

      (Smith et al., 1985)

      temperature-sensitive

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Baker.

      Selected as: temperature-sensitive lethal that shows an elevated frequency of homozygous mwh clones in the wing of mit(1)141/Y;mwh-/+ males.

      (Smith et al., 1985)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Zw1015
      l(1)zw10ts
      (Williams et al., 1992)
      mit(1)1515
      zw10ts
      (Smith et al., 1985)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)