FB2026_03 , released September 17, 2026
Allele: Dmel\mle6
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General Information
Symbol
Dmel\mle6
Species
D. melanogaster
Name
FlyBase ID
FBal0012339
Feature type
allele
Associated gene
Dmel\mle
Associated Insertion(s)
Carried in Construct
Also Known As
mle185
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mle1/mle6 males are temperature sensitive. At 18oC no significant lethality or sterility is observed. At 25oC males are viable but sterile, sperm are fully formed but non-motile. At 29oC no males reach adulthood, they die during late third instar and pupal stages.

      (Rastelli and Kuroda, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Presumed to encode a full length but inactive protein (T.R. Breen and J.C. Lucchesi, unpublished).

      (Gu et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mle185
      (Gu et al., 1998, Rastelli and Kuroda, 1998)
      mle6
      Name Synonyms
      Secondary FlyBase IDs
        References (5)