FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mle15
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General Information
Symbol
Dmel\mle15
Species
D. melanogaster
Name
FlyBase ID
FBal0012348
Feature type
allele
Associated gene
Dmel\mle
Associated Insertion(s)
Carried in Construct
Also Known As
mleRK
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kernan et al., 1991)
Progenitor genotype
Cytology
Description

Amino acid replacement: P385L.

(Richter et al., 1996)

Nucleotide substitution: C1574T. Amino acid replacement: P385L.

(Kernan et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:5,978,436..5,978,436 [-]
Nucleotide change:

C5978436T

Amino acid change:

P385L | mle-PA; P28L | mle-PC

Reported amino acid change:

P385L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kernan et al., 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Male lethal at the late third instar to early pupal stage. Homozygous female larvae are viable.

      (Chiang and Kurnit, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Mutant phenotype can be rescued by P element mediated transformation of a wild type mle gene copy.

      (Kernan et al., 1991)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Single amino acid change is responsible for the mutant phenotype: transgenic copy (P{HA-RK}) fails to bind to the X chromosome or to complement mle mutants.

      (Richter et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mle15
      mleRK
      (Chiang and Kurnit, 2003, Richter et al., 1996, Kernan et al., 1991)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)