FB2026_02 , released June 18, 2026
Allele: Dmel\mnb2
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General Information
Symbol
Dmel\mnb2
Species
D. melanogaster
Name
FlyBase ID
FBal0012365
Feature type
allele
Associated gene
Dmel\mnb
Associated Insertion(s)
P{}mnb2
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Tejedor et al., 1995)
Mutagen
PM hybrid dysgenesis
(Tejedor et al., 1995, Hoube and Fischbach, 1992, Zhu et al., 1991)
Progenitor genotype
Associated Insertion(s)
P{}mnb2
Cytology
Description

P-element insertion maps within exon 1 close to the transcription start site.

(Tejedor et al., 1995)

P-element insertion just downstream of the transcription start site.

(Zhu et al., 1991)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mnb2/mnb2 mutant larvae exhibit a significant increase in cell proliferation in the late third instar larval brain hemispheres, particularly in the outer proliferation center and central brain as compared to wild type.

      (Shaikh et al., 2016)

      Reduced brain volume, neuronal architecture has no gross alterations. External appearance is wild type, body size is slightly smaller than wild type. Mutants require 10% more time for their development and have considerable difficulty escaping from the pupal case. Adults exhibit defects in olfactory and visual behaviour. The neuroblast proliferation centre in larval brains is altered, unable to generate sufficient numbers of optic lobe and central brain neurons.

      (Tejedor et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mnb2
      (Shaikh et al., 2016)
      mnbUB913
      (Hoube and Fischbach, 1992, Zhu et al., 1991)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)