FB2026_02 , released June 18, 2026
Allele: Dmel\mus105A1
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General Information
Symbol
Dmel\mus105A1
Species
D. melanogaster
Name
FlyBase ID
FBal0012605
Feature type
allele
Associated gene
mus105
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Smith, 1976)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      mitosis & nuclear chromosome

      (Gatti, 1979)
      Detailed Description
      Statement
      Reference

      mus105A1 mutants have a similar frequency of single-strand annealing repair (SSA) compared to controls in a P{wIw.FRT} hemizygous assay to study DNA double-stranded break repair when assayed at 38oC.

      (Wei and Rong, 2007)

      Homozygotes and hemizygotes show a higher frequency of spontaneous chromosome aberrations in neuroblast metaphases than wild-type larvae. The ratio of chromatid breaks to isochromatid breaks is 1.9-2.5. Approximately 80% of the breaks are euchromatic. The breaks appear to be randomly distributed among the chromosomes. Breaks are 1.4-1.6 times more frequent in females than in males.

      (Gatti, 1979)

      Hemizygous male larvae are sensitive to methyl methanesulfonate (MMS). They show wild-type resistance to ultra violet (UV) light and some sensitivity to X rays. Only 0.2% of eggs laid by homozygous females develop into adults that eclose.

      (Smith, 1976)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Smith.

      Comments
      Comments

      Maternal germline clonal analysis demonstrates cell lethality in homozygous clones.

      (Perrimon et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      105A1
      (Gatti, 1979)
      mus(1)105A1
      (Smith, 1976)
      mus105A1
      (Wei and Rong, 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)