FB2026_02 , released June 18, 2026
Allele: Dmel\mus306D1
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General Information
Symbol
Dmel\mus306D1
Species
D. melanogaster
Name
FlyBase ID
FBal0012653
Feature type
allele
Associated gene
mus306
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Smith and Dusenbery, 1988, Boyd et al., 1981)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mus306D1 mutants have a similar frequency of single-strand annealing repair (SSA) compared to controls in a P{wIw.FRT} hemizygous assay to study DNA double-stranded break repair when assayed at 32oC, but show a reduced SSA frequency compared to controls when assayed at 38oC.

      (Wei and Rong, 2007)

      Excision repair capacity and post-replication repair capacity are normal.

      (Ferro and Eeken, 1993)

      A partial deficiency in the excision repair of pyrimidine dimers originally observed in this mutant is now attributed to the presence of a secondary phr mutation, phrmus306-D1.

      (Harris and Boyd, 1993)

      Larval survival is sensitive to methyl methanesulfonate.

      (Boyd et al., 1990)

      Flies are not sensitive to X rays.

      (Oliveri et al., 1990)

      Larval survival sensitive to exposure to methyl methanesulfonate. Displays hypermutability to alkylating agents; defective both in alkylation and UV excision repair pathways.

      (Smith and Dusenbery, 1988)

      Homozygotes fertile. Partially excision repair deficient.

      (Boyd and Harris, 1981)

      Sensitive to 0.075% methyl methanesulfonate. Not sensitive to 0.008% HN2.

      (Boyd et al., 1981)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      mus306D1/mus306D1 has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males.

      (McKee et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      306D1
      (McKee et al., 2000)
      mus306D1
      (Wei and Rong, 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (11)