FlyBase Allele Report: Dmel\N[fa-g62]

General Information

Symbol

Dmel\N^fa-g62

Species

D. melanogaster

Name

FlyBase ID

FBal0012870

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

flea{}N^fa-g62

Carried in Construct

Also Known As

fa^g2, fa^g-2

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Grimwade et al., 1985, Artavanis-Tsakonas et al., 1983)

Progenitor genotype

Associated Insertion(s)

flea{}N^fa-g62

Cytology

Description

Insertion of a transposable element into an intronic region between exons B and C of N.

(Ramos et al., 1989)

flea at -11.9 to -11.2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | heat sensitive

(Periz and Fortini, 1999)

visible | recessive

(Ramos et al., 1989)

Phenotype Manifest In

eye | heat sensitive

(Periz and Fortini, 1999)

lamina

(Markopoulou and Artavanis-Tsakonas, 1991)

lens | heat sensitive

(Periz and Fortini, 1999)

medulla

(Markopoulou and Artavanis-Tsakonas, 1991)

primary pigment cell

(Miller and Cagan, 1998)

secondary pigment cell | precursor

(Miller and Cagan, 1998)

tertiary pigment cell | precursor

(Miller and Cagan, 1998)

Detailed Description

Statement

Reference

N^fa-g62 mutant eyes do not display interommatidial pigment cell death.

(Peralta et al., 2009)

N^l1N-ts1/N^fa-g62 flies show a temperature sensitive roughening of the eye.

(Periz and Fortini, 1999)

Loss of primary pigment cell development and programmed cell death. Ablation of cone cells in four adjacent developing ommatidia at 20 hrs APF causes death of interommatidial precursor cells in wild type. This IPC death is blocked by N^fa-g62 or Ras85D^V12.hs.

(Miller and Cagan, 1998)

Interommatidial cells appear similar in shape to secondary pigment cells and are not sorted.

(Reiter et al., 1996)

N^l1N-ts1/N^fa-g62 females show a sharply temperature-dependent facet-eye phenotype: eyes are wild type up to 23^oC, but are facet-like at higher temperatures. Flies are fully viable and fertile at all temperatures tested.

(Fortini and Artavanis-Tsakonas, 1994)

Retina defects are not associated with optic lobe defects in 65.2% of homozygous N^fa-g62 retina clones generated by somatic recombination. The arrangement of ommatidia is severely disrupted, the number of ommatidia is reduced and they appear shorter than normal in homozygous clones in the retina. A disruption of the fenestrated zone, laminar cortex and neuropil can be seen in the underlying optic lobe if it is defective. Homozygous late pupae have normal optic lobe morphology, but the lamina neuropil is severely disrupted, containing large vacuoles, and the medulla neuropil contains small vacuoles in homozygous adults.

(Markopoulou and Artavanis-Tsakonas, 1991)

Like N^fa-g and cannot be distinguished from it. In heterozygotes with N mutants and in N^fa-g62/N^fa-g, the N^fa-g phenotype is exhibited; N^fa-g62/N^fa-1 has a N^fa-1 phenotype, and N^fa-g62/spl is wild type. strong allele; wings nicked; dosage compensated

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

N^fa-g62 is a suppressor of increased cell death phenotype of Chc⁴

(Peralta et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^I1

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^I1

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^S4

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^S4

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^AC1

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^AC1

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^AG2

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^AG2

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^AH2

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^AH2

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^AH7

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^AH7

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^AF1

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^AI5

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^AI5

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^AK1

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^AK1

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^AO5

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^AO5

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^AS2

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^AS2

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^AT1

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^AT1

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^AF1

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^A2

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^A2

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^D3

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^D3

(Periz and Fortini, 1999)

N^fa-g62 has eye phenotype, enhanceable by Ca-P60A[+]/SERCA^P2

(Periz and Fortini, 1999)

N^fa-g62 has lens phenotype, enhanceable by Ca-P60A[+]/SERCA^P2

(Periz and Fortini, 1999)

Suppressor of

Statement

Reference

N^fa-g62 is a suppressor of secondary pigment cell phenotype of Chc⁴

(Peralta et al., 2009)

N^fa-g62 is a suppressor of tertiary pigment cell phenotype of Chc⁴

(Peralta et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The retinal disorganisation and interommatidial pigment cell death observed in Chc⁴ mutant flies is suppressed by N^fa-g62.

(Peralta et al., 2009)

Ca-P60A alleles cause dominant eye roughening and maldeposition of lens material between adjacent lenses, typical of the 'facet' mutant phenotype, in a N^l1N-ts1/N^fa-g62 background at 23^oC.

(Periz and Fortini, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

N^fa-g62 is not rescued by N^mMGIIa

(Ramos et al., 1989)

Comments

The P{MGIIa} construct fails to rescue.

(Ramos et al., 1989)

Images (0)

Mutant

Wild-type

Stocks (2)

102

105735

Notes on Origin

Discoverer

Ives.

Comments

Removes N activity specifically in pigment cells.

(Miller and Cagan, 1998)

N^fa-g62 appears to act cell autonomously.

(Markopoulou and Artavanis-Tsakonas, 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

N^fa-g62

(Peralta et al., 2009)

fa^g-2

(Reiter et al., 1996, Meinertzhagen and Hanson, 1993, Markopoulou and Artavanis-Tsakonas, 1991, Grimwade et al., 1985)

fa^g2

(Periz and Fortini, 1999, Miller and Cagan, 1998, Fortini and Artavanis-Tsakonas, 1994, Ramos et al., 1989, Artavanis-Tsakonas et al., 1983)

fa^g62

swb^62b

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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