FlyBase Allele Report: Dmel\N[fa-swb]

General Information

Symbol

Dmel\N^fa-swb

Species

D. melanogaster

Name

facet-strawberry

FlyBase ID

FBal0012874

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

Also Known As

fa^swb

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

Progenitor genotype

Caused by aberration

Df(1)fa-swb

Cytology

Deficiency for interband between 3C6 and 7, causing these bands to fuse (Keppy and Welshons, 1977).

Description

Small deletion 5' of N.

(Reiter et al., 1996)

800bp deletion removing the 3' part of the gene immediately upstream of N and almost all of the sequences up to the N transcription start site.

(Gorman and Girton, 1992)

A complex event involving 2 deletions that result in a 880bp deletion at the distal end of N.

(Ramos et al., 1989)

Deletion of 0.8kb DNA from the 5' end of the N locus.

(Welshons and Welshons, 1986)

0.8kb deletion between coordinates -27.3 and -26.0 (zero coordinate is defined as the centre of the 2.2kb EcoRI fragment that encompasses the N^76b8 inversion breakpoint).

(Grimwade et al., 1985)

0.8 kb deletion in -28.4 to -27.1 Caused by a deficiency of 800 base pairs in the restriction fragment -- 26.2 to -- 25.0 (Grimwade, Muskavitch, Welshons, Yedvobnick and Artavanis-Tsakonas, 1985; this is 67 base pairs upstream from the start of transcription of Notch. Deletes the 3' end of the locus immediately to the left of N (Kidd, Kelley and Young, 1986).

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cJa

(Rousseaux et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Rabinow and Birchler, 1990)

visible | recessive

(Gorman and Girton, 1992, Ramos et al., 1989, Welshons and Welshons, 1986)

Phenotype Manifest In

eye

(Rabinow and Birchler, 1990, Ramos et al., 1989, Welshons and Welshons, 1986)

primary pigment cell

(Reiter et al., 1996)

Detailed Description

Statement

Reference

Differentiation of primary pigment cells varies between ommatidia.

(Reiter et al., 1996)

Disrupted transverse rows of bristles on the first tarsal segments, few extra sex cob bristles and rough eyes.

(Gorman and Girton, 1992)

Interacts with Df(1)rst2 to suppress eye roughening.

(Wolff and Ready, 1991)

Homozygotes exhibit rough eyes.

(Rabinow and Birchler, 1990)

Pronounced eye phenotype. Does not interact with dx^ENU.

(Xu and Artavanis-Tsakonas, 1990)

Phenotype is similar to N^fa-g; flies have rough, glossy eyes. The eye phenotype is less mutant in homozygous females than hemizygous males. N^fa-swb/N^fa-g flies have rough eyes that are not glossy.

(Welshons and Welshons, 1986)

In males, eyes are rough with a variable tendency to be glossy; with N^fa-g and N^fa-g62, eyes are very rough, but mutant condition is not as extreme as that found in homozygous glossy-eyed mutants. In heterozygotes with N^fa-1, eyes are slightly rough, overlapping wild type; with spl, the eyes are wild type. The N^fa-swb allele, like N^fa-1, is not dosage compensated and the mutant condition is poorly expressed in females. N^fa-swb/N^nd-3 has slight deltas at junction of longitudinal veins with marginal veins; in heterozygotes of N^fa-swb, N^55e11 and N^264-40, the eyes are glossy and the Notch phenotype is enhanced, resulting in reduced viability and fertility; with the temperature-sensitive N^60g11, heterozygotes are less mutant, viable, and fertile. In double mutants, N^fa-swb N^fa-g, the males have N^fa-g-like eyes; and wing veins are thickened and δ like at tips; they resemble N^nd-3 males except that wings are seldom notched. The wing-venation effect is less extreme in homozygous females (Welshons and Keppy, 1975; Keppy and Welshons, 1977). Removal of the region of 3C2-5 from the vicinity of N^fa-swb, either by deletion or inversion results in suppression of N^fa-swb; also affected by spontaneously arising, cis-acting enhancer ^e(fa<up>swb)</up> and suppressor ^su(fa<up>swb)</up> mutations, both of which map to the 3C2-5 region. (Welshons and Welshons, 1986).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

N^fa-swb has eye phenotype, enhanceable by e(fa^swb)¹

(Welshons and Welshons, 1986)

Suppressed by

Statement

Reference

N^fa-swb has phenotype, suppressible by In(1)78b

(Welshons and Welshons, 1986)

N^fa-swb has phenotype, suppressible by su(fa^swb)¹

(Welshons and Welshons, 1986)

Other

Statement

Reference

N^fa-swb, e(fa^swb)¹ has metathoracic tibia phenotype

(Welshons and Welshons, 1986)

N^fa-swb, e(fa^swb)¹ has microchaeta phenotype

(Welshons and Welshons, 1986)

Additional Comments

Genetic Interactions

Statement

Reference

Synergistic interactions with dx alleles.

(Gorman and Girton, 1992)

The phenotype is enhanced by e(fa^swb)¹; e(fa^swb)¹ in cis with N^fa-swb in either the homozygous or hemizygous condition produces flies with darkly pigmented, very rough, slightly narrow eyes. In addition there is a proliferation of microchaetae over the thorax, abdomen and legs, and the tibiae of the rear legs are distinctly bowed. The phenotype is suppressed by su(fa^swb)¹ in cis with N^fa-swb in either the homozygous or hemizygous condition. The phenotype is also suppressed by In(1)78b.

(Welshons and Welshons, 1986)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

N^fa-swb is rescued by N^+tCos479

(Ramos et al., 1989)

Not rescued by

N^fa-swb is not rescued by N^mMGIIa

(Ramos et al., 1989)

Comments

N^+tCos479 rescues the mutant phenotype but N^mMGIIa construct only partially rescues.

(Ramos et al., 1989)

N^fa-swb complements nd and N^nd-2.

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (1)

Bloomington

1715

w^a N^fa-swb

Notes on Origin

Discoverer

Lefevre and Kelley.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

N^fa-swb

(Volkova et al., 2019, Rousseaux et al., 2018, Tsubota et al., 2011, Popodi et al., 2010-)

fa^swb

(West et al., 2002, Vazquez and Schedl, 2000, Reiter et al., 1996, Gorman and Girton, 1992, Wolff and Ready, 1991, Rabinow and Birchler, 1990, Xu and Artavanis-Tsakonas, 1990, Ramos et al., 1989, Welshons and Welshons, 1986, Grimwade et al., 1985, Artavanis-Tsakonas et al., 1983)

facet^strawberry

(Dickson and Hafen, 1993)

swb^71b

Name Synonyms

facet-strawberry

Secondary FlyBase IDs

References (20)

Report Sections

Open Close