FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ndl2
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General Information
Symbol
Dmel\ndl2
Species
D. melanogaster
Name
FlyBase ID
FBal0012922
Feature type
allele
Associated gene
Dmel\ndl
Associated Insertion(s)
Carried in Construct
Also Known As
ndl093
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(LeMosy and Hashimoto, 2000)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: A4332T. Amino acid replacement: H1355L. Mutation is within the catalytic domain.

(LeMosy et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:6,598,319..6,598,319 [-]
Nucleotide change:

A6598319T

Reported nucleotide change:

A4332T

Amino acid change:

H1355L | ndl-PA

Reported amino acid change:

H1355L

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement.

(LeMosy et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous ndl2 follicle cell clones are produced via Scer\GAL4e22c-mediated expression of FLP recombinase. In some egg chambers all follicle cells appear to be mutant, indcating that ndl2 mutants do not confer any defect in viability or growth.

      Ventral follicle cells homozygous for the class II ndl2 allele do not perturb dorso-ventral patterning in the progeny embryos.

      (Stein et al., 2008)

      Allele is inactive in dorsoventral polarity establishment.

      (LeMosy et al., 2000)

      Injection of snkΔne.T:ea into the central region of homozygous embryos causes a lateralised/ventralised phenotype.

      (Smith and DeLotto, 1994)

      Embryos transplanted with perivitelline fluid from Tl2 embryos exhibit a polar gastrulation. At the end of embryogenesis an almost complete restoration of pattern along the dorsoventral axis is seen. The point of injection determines the ventralmost point of the restored pattern.

      (Stein et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When pipST2.Scer\UAS is expressed under the control of Scer\GAL4ET3 in ndl1/ndl2 females, the resulting embryos are dorsalised.

      (Sen et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Shows dominant negative inhibition of ndl9.

      (LeMosy et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Class II allele.

      (LeMosy et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (12)