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General Information
Symbol
Dmel\ndl2
Species
D. melanogaster
Name
FlyBase ID
FBal0012922
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ndl093
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

A6598319T

Reported nucleotide change:

A4332T

Amino acid change:

H1355L | ndl-PA

Reported amino acid change:

H1355L

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: A4332T. Amino acid replacement: H1355L. Mutation is within the catalytic domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous ndl2 follicle cell clones are produced via Scer\GAL4e22c-mediated expression of FLP recombinase. In some egg chambers all follicle cells appear to be mutant, indcating that ndl2 mutants do not confer any defect in viability or growth.

Ventral follicle cells homozygous for the class II ndl2 allele do not perturb dorso-ventral patterning in the progeny embryos.

Allele is inactive in dorsoventral polarity establishment.

Injection of snkΔne.T:ea into the central region of homozygous embryos causes a lateralised/ventralised phenotype.

Embryos transplanted with perivitelline fluid from Tl2 embryos exhibit a polar gastrulation. At the end of embryogenesis an almost complete restoration of pattern along the dorsoventral axis is seen. The point of injection determines the ventralmost point of the restored pattern.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

When pipST2.Scer\UAS is expressed under the control of Scer\GAL4ET3 in ndl1/ndl2 females, the resulting embryos are dorsalised.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Shows dominant negative inhibition of ndl9.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Class II allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (12)