FlyBase Allele Report: Dmel\pb[18]

General Information

Symbol

Dmel\pb¹⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0013522

Feature type

allele

Associated gene

Dmel\pb

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Cribbs et al., 1992)

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Amino acid replacement: R228W.

(Tayyab et al., 2004)

Coordinates of the lesion are the position in the 2-μ-4a spliced form of pb.

(Tayyab et al., 2004)

Nucleotide substitution: A682T.

(Tayyab et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:6,711,834..6,711,834 [-]

Nucleotide change:

A6711834T

Reported nucleotide change:

A682T

Amino acid change:

R228W | pb-PA; R223W | pb-PB; R223W | pb-PC; R218W | pb-PD

Reported amino acid change:

R228W

Comment:

Reported coordinates are with respect to pb-RA and pb-PA.

(Tayyab et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with pb²⁰)

(Tayyab et al., 2004)

Phenotype Manifest In

arista | ectopic (with pb²⁰)

(Tayyab et al., 2004)

labellum

(Cribbs et al., 1992)

maxillary palp (with pb²⁰)

(Tayyab et al., 2004)

proboscis (with pb²⁰)

(Tayyab et al., 2004)

pseudotrachea (with pb²⁰)

(Tayyab et al., 2004)

tarsal segment | ectopic (with pb²⁰)

(Tayyab et al., 2004)

Detailed Description

Statement

Reference

pb¹⁸/pb²⁰ flies have a hypomorphic phenotype; the maxillary palps are vestigial, the proboscis is transformed into aristae or tarsi, and the number of pseudotracheal rows is reduced to one or two.

(Tayyab et al., 2004)

The labial palp is transformed to prothoracic leg.

(Cribbs et al., 1992)

leg

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Matthews.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

(Cribbs et al., 1992)

pb¹⁸

(Tayyab et al., 2004)

pb^m2

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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