FB2026_02 , released June 18, 2026
Allele: Dmel\pb35
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General Information
Symbol
Dmel\pb35
Species
D. melanogaster
Name
FlyBase ID
FBal0013539
Feature type
allele
Associated gene
Dmel\pb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Cribbs et al., 1992)
Mutagen
X ray
Progenitor genotype
Cytology

Polytene chromosomes normal.

Description

Nucleotide substitution A1117G, plus insertion of 5 nucleotides between nucleotides 1581 and 1584: G(1581)agtaCCtA(1584) (lowercase nucleotides are the inserted bases). This results in the missense mutation K373E and a frameshift at amino acid residue 528 which produces a stop codon at residue 530. Coordinates of the lesions are the position in the 2-μ-4a spliced form of pb.

(Tayyab et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
insertion
3R:6,709,933..6,709,936 [-]
Comment:

A five base insertion causes a frameshift and early translation termination. GCCA becomes GagtaCCtA, where the inserted nucleotides are in lower case. One of two lesions characterized in mutant.

(Tayyab et al., 2004)
point_mutation
3R:6,710,627..6,710,627 [-]
Nucleotide change:

A6710627G

Reported nucleotide change:

A1117G

Amino acid change:

K373E | pb-PA; K368E | pb-PB; K368E | pb-PC; K363E | pb-PD

Reported amino acid change:

K373E

Comment:

One of two lesions characterized in mutant.

(Tayyab et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pb35/pb20 flies have vestigial maxillary palps, the labellar caps are weakly transformed to tarsi (claws and pulvilli form, but the tarsi are short and stumpy and sometimes arista-like structures are observed) and the pseudotracheae are missing.

      (Tayyab et al., 2004)

      The labial palp is transformed to prothoracic leg.

      (Cribbs et al., 1992)

      leg

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Kaufman.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      pb35
      (Tayyab et al., 2004)
      pbwin5
      win5
      (Cribbs et al., 1992)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)