FB2026_02 , released June 18, 2026
Allele: Dmel\pch4
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General Information
Symbol
Dmel\pch4
Species
D. melanogaster
Name
FlyBase ID
FBal0013581
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes frequently fail to escape from the puparium and die during eclosion. This mortality increases under desiccated conditions and decreases under humid conditions. Homozygous flies are more sensitive to desiccation than wild-type; all flies die within 3 hours under desiccated conditions without a water supply, in contrast to wild-type where 50% survive for more than 15 hours under the same conditions. Flies survive longer in a moist environment conditions without a water supply than in the desiccated environment. There are no significant qualitative differences in the cuticular hydrocarbons of pch4 and wild-type flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

The phenotype of homozygous pch4 flies suggests that they have a defect in a waterproofing mechanism of the integument.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
pch4
Name Synonyms
Secondary FlyBase IDs
    References (2)