FlyBase Allele Report: Dmel\Pu[rP42]

General Information

Symbol

Dmel\Pu^rP42

Species

D. melanogaster

Name

FlyBase ID

FBal0014026

Feature type

allele

Associated gene

Dmel\Pu

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Mackay et al., 1985)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color | recessive

(Mackay et al., 1985)

lethal - all die during embryonic stage

(O'Donnell et al., 1989, Reynolds and O'Donnell, 1987)

lethal - all die during embryonic stage | recessive

(Mackay et al., 1985)

some die during embryonic stage

(O'Donnell et al., 1989, Reynolds and O'Donnell, 1987)

some die during embryonic stage | recessive

(Mackay et al., 1985)

visible | recessive

(Mackay et al., 1985)

Phenotype Manifest In

cuticle

(Reynolds and O'Donnell, 1987)

embryonic/first instar larval cuticle

(O'Donnell et al., 1989)

head

(Reynolds and O'Donnell, 1987)

pigment cell

(Mackay et al., 1985)

Detailed Description

Statement

Reference

Embryos have completely unpigmented and weak cuticles.

(O'Donnell et al., 1989)

Defects in cuticular pigmentation, head differentiation and internal organization.

(Reynolds and O'Donnell, 1987)

Eye colour: mutant in trans with a homozygous viable Pu allele.

(Mackay et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

GTP cyclohydrolase activity is reduced in the prepupa, adult body and adult head of heterozygotes. The viability and eye phenotype in trans with other Pu alleles has been determined.

(Mackay et al., 1985)

Class III Pu allele.

(Reynolds and O'Donnell, 1987)

Class III allele.

(O'Donnell et al., 1989)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pu^P42

(Reynolds and O'Donnell, 1987)

Pu^rP42

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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