FB2026_03 , released September 17, 2026
Allele: Dmel\ref(2)Pn
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General Information
Symbol
Dmel\ref(2)Pn
Species
D. melanogaster
Name
FlyBase ID
FBal0014526
Feature type
allele
Associated gene
Dmel\ref(2)P
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Wayne et al., 1996, Dru et al., 1993)
Progenitor genotype
Cytology
Description

Sequence of a cDNA from ref(2)Pn was compared to the sequence of ref(2)Pp, and the only difference found was that the 21bp deletion of ref(2)Pp was not evident in ref(2)Pn. A CGC in the not-deleted 21bp corresponds to a CGC in the ref(2)Po2 allele, which is an AGC in ref(2)Po1.

(Dru et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
sequence_variant
2L:19,545,073..19,545,073 [+]
Nucleotide change:

C19541002G

Amino acid change:

D542E | ref(2)P-PA; D542E | ref(2)P-PB

Comment:

One of several differences between permissive ref(2)Po and restrictive ref(2)Pn strains.

(Dru et al., 1993)
sequence_variant
2L:19,542,898..19,542,903 [+]
Comment:

Replaced with "GGA" in ref(2)Pn strain which is restrictive for sigma virus replication. One of several differences between permissive ref(2)Po and restrictive ref(2)Pn strains.

(Dru et al., 1993)
sequence_variant
2L:19,542,910..19,542,910 [+]
Nucleotide change:

A19538839G

Amino acid change:

I32V | ref(2)P-PA; I32V | ref(2)P-PB

Comment:

One of several differences between permissive ref(2)Po and restrictive ref(2)Pn strains.

(Dru et al., 1993)
sequence_variant
2L:19,542,944..19,542,944 [+]
Nucleotide change:

A19538873T

Amino acid change:

Q43L | ref(2)P-PA; Q43L | ref(2)P-PB

Comment:

One of several differences between permissive ref(2)Po and restrictive ref(2)Pn strains.

(Dru et al., 1993)
sequence_variant
2L:19,544,138..19,544,138 [+]
Nucleotide change:

A19540067T

Amino acid change:

T231S | ref(2)P-PA; T231S | ref(2)P-PB

Comment:

One of several differences between permissive ref(2)Po and restrictive ref(2)Pn strains.

(Dru et al., 1993)
sequence_variant
2L:19,544,438..19,544,438 [+]
Nucleotide change:

A19540367C

Amino acid change:

S331R | ref(2)P-PA; S331R | ref(2)P-PB

Comment:

One of several differences between permissive ref(2)Po and restrictive ref(2)Pn strains.

(Dru et al., 1993)
sequence_variant
2L:19,544,647..19,544,670 [+]
Comment:

Deletion of 24bp in ref(2)Pn strain which is restrictive for sigma virus replication. One of several differences between permissive ref(2)Po and restrictive ref(2)Pn strains.

(Dru et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
X69830
CAA49484
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Restrictive for sigma virus multiplication. CO2 resistant.

    (Dru et al., 1993)

    restrictive allele

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer

    Isolated from: Nagasaki population.

    Comments
    Comments

    ref(2)Po and ref(2)Pn are the most frequent alleles found in nature in Europe.

    (Dru et al., 1993)

    Restrictive (resistant) line to the sigma virus, determined by a CO2 sensitivity assay.

    (Wayne et al., 1996)
    External Crossreferences and Linkouts ( 3 )
    Crossreferences
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    ref(2)Pn
    (Carre-Mlouka et al., 2007)
    Name Synonyms
    Secondary FlyBase IDs
      References (4)