FlyBase Allele Report: Dmel\kni[ri-53j]

General Information

Symbol

Dmel\kni^ri-53j

Species

D. melanogaster

Name

FlyBase ID

FBal0014571

Feature type

allele

Associated gene

Dmel\kni

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

Single base pair alteration (C to A) within fragment "E" of the kni putative upstream regulatory sequences.

(Lunde et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:20,707,276..20,707,276 [-]

Nucleotide change:

G20707276T

Reported nucleotide change:

C596A

Comment:

Single base pair change in the putative regulatory region for wing vein L2 expression. Regulatory region with point muation when placed in reporter construct, fails to drive expression in wing vein L2. (Note that the reported base change is on the opposite strand and in relation to the EcoRI-XhoI fragment.)

(Lunde et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Lunde et al., 2003)

visible

(Lunde et al., 2003)

Phenotype Manifest In

wing vein L2

(Lunde et al., 2003)

Detailed Description

Statement

Reference

Mutant adults lack portions of the L2 wing vein.

(Lunde et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Meyer, Oct. 1953.

Separable from: CG13252^53j. The "kni^ri-53j" chromosome contains two lesions, one is a single base pair change in the kni vein L2 enhancer (resulting in the kni^ri-53j allele), one is a deletion of approximately 50bp within an intron of CG13252 (CG13252^53j allele), further upstream of the kni transcription unit. The ubiquitous expression of CG13252 is not affected in mutants carrying the "kni^ri-53j" chromosome and a genomic fragment of the region where the 50bp deletion is located fused to a reporter gene does not result in reporter gene expression in the wing vein L2 primordium, so there is no evidence that the 50bp deletion has any relevance to the wing vein L2 loss phenotype of kni^ri-53j mutants.

(Lunde et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

kni^ri-53j

kni^ri[53j]

(Lunde et al., 2003)

ri^53j

(Trimble and Bier, 2003)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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