FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Polr2AK2
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General Information
Symbol
Dmel\Polr2AK2
Species
D. melanogaster
Name
FlyBase ID
FBal0014776
Feature type
allele
Associated gene
Dmel\Polr2A
Associated Insertion(s)
Carried in Construct
Also Known As
WJK2
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Chen et al., 1993, Mortin et al., 1988)
Progenitor genotype
Cytology
Description

Amino acid replacement: L820F. Nucleotide substitution: C4273T.

(Chen et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,566,846..11,566,846 [-]
Nucleotide change:

C11566846T

Reported nucleotide change:

C4273T

Amino acid change:

L820F | Polr2A-PA

Reported amino acid change:

L820F

(Chen et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Exhibits the Ubx effect: heterozygotes partially transform the capitellum of the haltere into the wing blade.

      (Chen et al., 1993)

      Homozygous and hemizygous viable. The capitellum of the haltere shows a partial transformation to wing blade in heterozygotes. Enhances the bristle duplication phenotype of Dl7 heterozygotes.

      (Mortin et al., 1988)

      Homozygous and hemizygous viable; homozygous females sterile. Exhibits slight enhancement of Ubx when heterozygous to + but not in heteroallelic combination with any of the interacting mutant alleles; it decreases the enhancing effects of RpII215Ubl. Increases the number of duplicated bristles of Dl/+ in all genotypes. Temperature-sensitive period for effects on both Ubx and Dl from third larval instar until mid-pupal stage. viable female-sterile

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Kim.

      Comments
      Comments

      Degree of transformation of the haltere when heterozygous: RpII215H1 < RpII2157 < RpII215K2 < RpII2154 < RpII215Ubl.

      (Mortin et al., 1988)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Polr2AK2
      RpII215K2
      RpII215WJK2
      WJK2
      (Chen et al., 1993, Mortin et al., 1988)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)