FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Scr6
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General Information
Symbol
Dmel\Scr6
Species
D. melanogaster
Name
FlyBase ID
FBal0015282
Feature type
allele
Associated gene
Dmel\Scr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

cold sensitive hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

cold sensitive hypomorphic allele - genetic evidence

(Pattatucci et al., 1991)
Mutagen
ethyl methanesulfonate
(Pattatucci et al., 1991)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Pattatucci et al., 1991)
Description

Amino acid replacement: M395K.

(Sivanantharajah and Percival-Smith, 2009)

Nucleotide substitution: T1184A.

(Sivanantharajah and Percival-Smith, 2009)

Amino acid replacement: F405I.

(Sivanantharajah and Percival-Smith, 2009)

Nucleotide substitution: T1213A.

(Sivanantharajah and Percival-Smith, 2009)

Nucleotide substitution: G1239T.

(Sivanantharajah and Percival-Smith, 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,825,423..6,825,423 [-]
Nucleotide change:

T6825423A

Reported nucleotide change:

T1213A

Amino acid change:

F405I | Scr-PA; F405I | Scr-PB; F405I | Scr-PD; F405I | Scr-PE; F405I | Scr-PF

Reported amino acid change:

F405I

Comment:

Three nucleotide changes reported in mutant, two missense mutations and one silent substitution (G1239T).

(Sivanantharajah and Percival-Smith, 2009)
point_mutation
3R:6,825,452..6,825,452 [-]
Nucleotide change:

T6825452A

Reported nucleotide change:

T1184A

Amino acid change:

M395K | Scr-PA; M395K | Scr-PB; M395K | Scr-PD; M395K | Scr-PE; M395K | Scr-PF

Reported amino acid change:

M395K

Comment:

Three nucleotide changes reported in mutant, two missense mutations and one silent substitution (G1239T).

(Sivanantharajah and Percival-Smith, 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ138.UAS.mRFP1
      (Weiss et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scr6/Df(3R)WIN3 males have a reduction in the number of sex comb bristles on the prothoracic leg compared to wild-type males.

      (Sivanantharajah and Percival-Smith, 2009)

      Prothoracic to mesothoracic, pronotal to mesonotal and labial to maxillary transformations. Slight decrease in viability at the permissive temperature, 29oC, and lethality at the restrictive temperature, 18oC. Polyphasic semi-lethality.

      (Pattatucci et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scr6/Scr[+] is a suppressor | partially of lethal | pharate adult stage phenotype of Hsap\HTTQ138.UAS.mRFP1, Scer\GAL4elav-C155

      (Weiss et al., 2012)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      One copy of Scr6 partially rescues the lethality seen when Hsap\HTTQ138.Scer\UAS.T:Disc\RFP-mRFP is expressed under the control of Scer\GAL4elav-C155 using the P{UAS-HTT.Q138.mRFP}A insertion line.

      (Weiss et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Fornili.

      (Lindsley and Zimm, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Scr6
      (Weiss et al., 2012, Sivanantharajah and Percival-Smith, 2009)
      Scrf2ts
      (Pattatucci et al., 1991)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)