FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Scr8
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General Information
Symbol
Dmel\Scr8
Species
D. melanogaster
Name
FlyBase ID
FBal0015284
Feature type
allele
Associated gene
Dmel\Scr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

cold sensitive hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

cold sensitive hypomorphic allele - genetic evidence

(Pattatucci et al., 1991)
Mutagen
ethyl methanesulfonate
(Pattatucci et al., 1991)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Pattatucci et al., 1991)
Description

Amino acid replacement: A288T.

(Sivanantharajah and Percival-Smith, 2009)

Nucleotide substitution: G862A.

(Sivanantharajah and Percival-Smith, 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,841,319..6,841,319 [-]
Nucleotide change:

G6841319A

Reported nucleotide change:

G862A

Amino acid change:

A288T | Scr-PA; A288T | Scr-PB; A288T | Scr-PD; A288T | Scr-PE; A288T | Scr-PF

Reported amino acid change:

A288T

(Sivanantharajah and Percival-Smith, 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous and Scr8/Df(3R)WIN3 males have no sex comb bristles on the prothoracic leg.

      The number of nuclei in the salivary glands of Scr8/Df(3R)WIN3 larvae is not significantly different from normal.

      Scr8/Df(3R)WIN3 flies have a reduced number of rows of pseudotrachea on the proboscis compared to controls. This phenotype is cold sensitive

      Scr8/Scr13A flies have a reduced number of rows of pseudotrachea on the proboscis compared to controls.

      (Sivanantharajah and Percival-Smith, 2009)

      Scr8/ScrWrv5 transheterozygous pharate adults dissected from the pupal case exhibit ectopic wing formation in the dorsal anterior region of the prothorax, just ventral to the tergite in the dorsal pleuron. A normal wing forms in the mesothorax.

      (Rogers et al., 1997)

      Prothoracic to mesothoracic, pronotal to mesonotal and labial to maxillary transformations. Slight decrease in viability at the permissive temperature, 29oC, and lethality at the restrictive temperature, 18oC. Polyphasic semi-lethality.

      (Pattatucci et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Fornili.

      (Lindsley and Zimm, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Scr8
      (Sivanantharajah and Percival-Smith, 2009)
      Scrf76ts
      (Pattatucci et al., 1991)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)