FlyBase Allele Report: Dmel\Scr[S]

General Information

Symbol

Dmel\Scr^S

Species

D. melanogaster

Name

FlyBase ID

FBal0015307

Feature type

allele

Associated gene

Dmel\Scr

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

gain of function allele

Mutagen

diepoxybutane

Nature of the Allele

Allele class

gain of function allele

(Ragab et al., 2006, Pattatucci et al., 1991)

Mutagen

diepoxybutane

(Pattatucci et al., 1991)

Progenitor genotype

Caused by aberration

Tp(2;3)Scr^S

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant | homeotic

(Decoville et al., 2001)

Phenotype Manifest In

mesothoracic leg

(Decoville et al., 2001)

mesothoracic leg & sex comb tooth | ectopic

(Ragab et al., 2006)

metathoracic leg

(Decoville et al., 2001)

metathoracic leg & sex comb tooth | ectopic

(Ragab et al., 2006)

sex comb | ectopic

(Decoville et al., 2001, Pattatucci et al., 1991)

sternopleural bristle

(Pattatucci et al., 1991)

Detailed Description

Statement

Reference

Scr^S/+ males have sex combs on the second and third legs instead of just on the first.

(Ragab et al., 2006)

100% of T3 legs have a sex comb in heterozygous males. Mesothoracic legs also have sex combs.

(Decoville et al., 2001)

Dominant allele.

(Lindsley and Zimm, 1992)

Ectopic sex comb teeth on males, disruption or removal of sternopleural and mesosternal bristles on males and females.

(Pattatucci et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scr^S has visible | dominant | homeotic phenotype, suppressible by Dsp1¹

(Decoville et al., 2001)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scr^S has mesothoracic leg & sex comb tooth | ectopic phenotype, suppressible by +/Df(2R)ED3923

(Ragab et al., 2006)

Scr^S has metathoracic leg & sex comb tooth | ectopic phenotype, suppressible by +/Df(2R)ED3923

(Ragab et al., 2006)

Scr^S has mesothoracic leg phenotype, suppressible by Dsp1¹

(Decoville et al., 2001)

Scr^S has metathoracic leg phenotype, suppressible by Dsp1¹

(Decoville et al., 2001)

Scr^S has sex comb | ectopic phenotype, suppressible by Dsp1¹

(Decoville et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The Df(2R)ED3923 deficiency partially suppresses the Scr^S ectopic sex comb tooth phenotype in a dose dependent manner.

(Ragab et al., 2006)

Dsp1¹/Y ; Scr^S/+ males have a less severe phenotype than Scr^S/+ single mutants; the number of T3 legs with a sex comb is highly diminished (30 vs 100%) and the size of the sex comb on the T2 legs is reduced (2.5 vs 4.5 teeth).

(Decoville et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

3384

kni^ri-1 Scr^S e¹/TM6B, Tb¹

Notes on Origin

Discoverer

Seeger.

(Lindsley and Zimm, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Scr^S

Scr^ms1

(Pattatucci et al., 1991)

Scr^msl

(Lindsley and Zimm, 1992)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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