Amino acid replacement: V1055S.
furrow canal & egg | maternal effect
Females, homozygous for scra6, lay morphologically normal eggs that fail to hatch. These mutant embryos exhibit cellularisation defects. Despite defects in furrow canal structure and septin targeting, the cellularisation front still ingresses in scra6/scra6 mutant embryos. In comparison to wild-type, the initiation phase of ingression is eliminated. Instead, a cellularisation front begins to ingress as soon as mitosis is completed, at a roughly constant slow rate. A distinct transition to a faster rate can be observed, but both slow and fast rates of ingression are slower than their wild-type counterparts.
Eggs derived from homozygous females form a syncytial blastoderm and begin to cellularise normally, but cellularisation is often not completed. Gastrulation takes place but is usually very abnormal. The embryos form pieces of cuticle.
scra6 is rescued by scrafl.cFa
All the embryos from scra6 homozygous mothers that receive scrafl.cFa are rescued to hatching, and approximately 90% of these develop into fertile adults.
Based on adult viability, and common cellularisation defects, the following scra alleles can be ranked from strongest to weakest as follows: scra7 = scra8 > scra03427 > scra5 = scra4 > scra1 > scra3 = scra6 = scraB26-35 = scraC82-45.