Amino acid replacement (G to S) at a position that corresponds to residue 169 in the B isoform, and residue 214 in the C isoform (not applicable to the A isoform).
G22812714A
G214S | stl-PC; G214S | stl-PE
G169S
G214S
2R_r5:18700219..18700219
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The amino acid sequence changes were reported with respect to three alternative transcripts to which it applies.
Mutant ovarioles in adult females lack the interfollicular stalks that normally separate adjacent wild-type follicles. This phenotype results from failed follicle individualisation, rather than from persistent germline cell division, because mutant ovarioles contain germ cells at varying stages of maturation and groups of 16 interconnected germ cells that would correspond to a single germline cyst in wild-type are still recognisable. Degeneration is seen in the mutant ovarioles, which increases with age, and both germline and somatic cells appear to degenerate.
Ovarian tumours, or egg chambers with variable numbers of nurse cells.
female-sterile ovarian tumors; ovarioles filled with small undifferentiated cells, as well as egg chambers containing variable numbers of nurse cells and degenerating material. Occasional normal egg chambers take up yolk, but form abnormal, collapsing eggs which remain unfertilized. homozygous females often contain
